Hypothalamic Obesity is caused by damage to an area at the base of the brain called the hypothalamus. This area, the size of a fingernail, whose primary function is to release hormones which control the function of the pituitary gland immediately below it, also controls energy balance.
Damage to this area has long been known to promote excessive eating (hyperphagia) and weight gain. According to doctors, this form of weight gain is not responsive to diet and exercise. Victims of this form of obesity continue to gain weight despite their best efforts, and suffer greatly from this unrelenting scourge.